New Extractive Method Development of Sitagliptin Phosphate in API and Its Unit Dosage Forms by Spectrophotometry

Determination of Sitagliptin Phosphate in Bulk Drugs by Extractive Spectrophotometric Method

An extractive spectrophotometric method is described for the assay of sitagliptin phosphate in bulk drug and in tablets. Sitagliptin phosphatewas extracted as an ion-pair complex from the solution containing Eriochrome black T and 0.1N HCl into chloroform and the absorbance of the complex was measured at 500nm.The working conditions of the method were investigated and optimized. Beer’s law plot...

solution of security constrained unit commitment problem by a new multi-objective optimization method

چکیده-پخش بار بهینه به عنوان یکی از ابزار زیر بنایی برای تحلیل سیستم های قدرت پیچیده ،برای مدت طولانی مورد بررسی قرار گرفته است.پخش بار بهینه توابع هدف یک سیستم قدرت از جمله تابع هزینه سوخت ،آلودگی ،تلفات را بهینه می کند،و هم زمان قیود سیستم قدرت را نیز برآورده می کند.در کلی ترین حالتopf یک مساله بهینه سازی غیر خطی ،غیر محدب،مقیاس بزرگ،و ایستا می باشد که می تواند شامل متغیرهای کنترلی پیوسته و گ...

Correlation of results between validated in-house analysis method with new pharmacopeia monograph for analysis of Sitagliptin Phosphate API

Having validated analysis methods for medicinal ingredients is attractive for pharmaceutical companies. When a new molecule is introduced to the market, there is not any pharmacopeial analysis method for that. After publishing official methods, correlation between validated in-house methods and the official one could stablish the value of the in-house method. Sitagliptin phosphate is a new anti...

Method development and estimation of Sitagliptin phosphate in bulk and Pharmaceutical dosage forms using UV-VIS spectrophotometer

The present study describes a simple, accurate, precise and cost effective UV-VIS Spectrophotometric method for the estimation of Sitagliptin phosphate, an anti diabetic drug, in bulk and pharmaceutical dosage form. The solvent used was distilled water and acetic acid in ratio of 80:20 and the λmax or the absorption maxima of the drug was found to be 268nm. A linear response was observed in the...

determination of sitagliptin phosphate in bulk drugs by extractive spectrophotometric method